”Theirs was not to make reply, Theirs was not to reason why.”

Background: In 1974, the United States passed Research Act, which required creating and implementing guidelines for conducting research on humans animals. 1978, universities hospitals created Institutional Review Boards reviewing approving protocols in States. Objectives: This article will define explain components of a protocol, team member roles responsibilities, pre-protocol submission training requirements, provide suggestions improving how researchers obtain approval. Lessons Learned: The author failed to all information before collecting Informed Consent prospective participants four different study protocols. Conclusions: Obtaining approval is necessary most designs. It complex frequently tedious process, but obtaining gives studies greater credibility.